Well I have listened to the last podcast on Youtube. To be more correct this podcast is actually a lecture by Pro. Randy Pausch, it is hour and a half lecture. He was a Pro to computer science when he died of cancer. The first thing that got me while watching is when he started the lecture the crowd stood and gave him applause so he said to them "make me earn it" and they said back:" You did". The man is so smart and will leave you amazed but yet he was so humble and modest despite all what he had.
The lecture is about the life, how to deal with our problems in life and the main thing is how to realize our dreams. He shares with us experiences from his own personal life but at the end he does something very tricky.
I highly recommend seeing it, there is the book which called also the last lecture.